CNGB3

Across TCGA cell cohorts, CNGB3 mutation is significantly associated with the RNA expression of many other genes, with 657 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNGB3-associated genes across cancer lineages are SEMG2, SLC36A3, and SMIM23. Each is linked with CNGB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNGB3-to-partner and partner-to-CNGB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMG2 grouped by CNGB3-low versus CNGB3-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNGB3→partner) and Y-score (partner→CNGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SEMG2 →	+0.023	+4.807	<.001	.006	3	2
LUNG_SCLC	SLC36A3 →	+0.012	+3.169	.001	.005	3	2
BLOOD_Leukemia	SMIM23 →	+0.011	+3.984	<.001	.006	3	2
LARGE_INTESTINE	RPL3 →	+0.521	+3.067	.002	.009	3	2
LARGE_INTESTINE	BBS7 →	+0.667	+3.364	.001	.002	3	2
LARGE_INTESTINE	NUP54 →	+0.586	+3.364	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 657 associations by consensus.

SEMG2 by CNGB3 expression — BLOOD_Myeloma

Explore this box plot interactively →