CNGB1

Across TCGA pan-cancer cohorts, CNGB1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated CNGB1 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher CNGB1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CNGB1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

THYM, UCEC, and DLBC are the cancer types where CNGB1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	0.969	0.822	.003	36	view →
DLBC	OS	Median	II,III,IV	0.115	0.839	<.001	12	view →
KIRC	OS	Median	All	0.167	0.655	.038	12	view →
SARC	OS	Median	All	0.108	0.839	<.001	12	view →
LIHC	DFS	Median	II,III,IV	0.094	0.429	.016	12	view →
HNSC	OS	Median	IV	0.210	0.641	.021	9	view →
SCLC	DFS	Median	III,IV	1.000	0.211	.023	4	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

CNGB1–THYM (OS)

Open the THYM breakdown →