CNGA4

Across TCGA patient cohorts, CNGA4 mutation is significantly associated with the RNA expression of many other genes, with 6,190 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNGA4-associated genes across cancer lineages are LIAS, CHAF1A, and RANGAP1. Each is linked with CNGA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both CNGA4-to-partner and partner-to-CNGA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIAS grouped by CNGA4-low versus CNGA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNGA4→partner) and Y-score (partner→CNGA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LIAS →	+0.396	+2.860	<.001	.001	3	4
UCEC	CHAF1A →	+0.830	+4.928	<.001	<.001	3	4
SKCM	RANGAP1 →	+0.525	+3.523	.001	.002	3	3
UCEC	DAD1 →	+0.371	+2.534	.001	<.001	3	3
UCEC	LACTB →	+0.555	+3.201	<.001	<.001	3	3
STAD	GOT1 →	+0.522	+3.338	.009	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,190 associations by consensus.

LIAS by CNGA4 expression — UCEC

Explore this box plot interactively →