CNGA4

Across TCGA patient cohorts, CNGA4 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNGA4-associated genes across cancer lineages are GAPDH, EGFR_pY1068, and eEF2. Each is linked with CNGA4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNGA4-to-partner and partner-to-CNGA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by CNGA4-low versus CNGA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNGA4→partner) and Y-score (partner→CNGA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.399	+3.459	.039	.005	3	3
COAD	EGFR_pY1068 →	-0.321	-2.309	.019	.033	3	3
SKCM	eEF2 →	+0.328	+3.000	.022	.035	3	2
COAD	INPP4B →	-0.476	-3.169	.002	.017	3	2
UCEC	MEK1 →	+0.437	+2.321	<.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.136	-1.794	.011	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

GAPDH by CNGA4 expression — UCEC

Explore this box plot interactively →