Across TCGA pan-cancer cohorts, CNGA2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CNGA2’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where CNGA2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CNGA2 is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.
BRCA, KICH, and UCEC are the cancer types where CNGA2 tumor–normal differential expression is most reproducible.