CNFN

Across TCGA pan-cancer cohorts, CNFN RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CNFN data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher CNFN RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CNFN expression acts as an unfavorable survival marker, although some lineages such as CESC and HNSC show a favorable association.

CESC, UCS, and SKCM are the cancer types where CNFN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Quartile	III,IV	0.927	0.397	<.001	58	view →
UCS	DFS	Median	IV	0.367	0.952	.001	38	view →
SKCM	OS	Median	All	0.723	0.835	<.001	36	view →
HNSC	OS	Median	All	0.527	0.285	.001	31	view →
OV	DFS	Tertile	II,III,IV	0.500	0.600	.012	30	view →
LUAD	DFS	Quartile	All	0.516	0.189	.004	30	view →
MESO	OS	Median	II,III,IV	0.463	0.660	.003	28	view →
KIRC	DFS	Median	All	0.731	0.854	.002	24	view →
GBM	OS	Tertile	All	0.272	0.541	.008	9	view →
CHOL	DFS	Tertile	III,IV	0.779	0.162	.024	9	view →
KICH	DFS	Median	II,III,IV	0.662	1.000	.015	8	view →
LUSC	OS	Quartile	All	0.714	0.559	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CNFN–CESC (DFS)

Open the CESC breakdown →