CMTR2

Across TCGA patient cohorts, CMTR2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMTR2-associated genes across cancer lineages are Paxillin, Cyclin-B1, and FoxM1. Each is linked with CMTR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CMTR2-to-partner and partner-to-CMTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Paxillin grouped by CMTR2-low versus CMTR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMTR2→partner) and Y-score (partner→CMTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Paxillin →	+0.251	+1.925	.007	.005	3	3
UCEC	Cyclin-B1 →	+0.736	+2.906	<.001	.001	3	2
UCEC	FoxM1 →	+0.262	+2.321	.004	.001	3	2
UCEC	Ku80 →	+0.228	+1.598	.007	.011	3	2
UCEC	Notch1 →	+0.136	+2.009	.007	.017	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.337	-1.571	.037	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Paxillin by CMTR2 expression — UCEC

Explore this box plot interactively →