CMTR2

Across TCGA cell cohorts, CMTR2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible CMTR2-associated genes across cancer lineages are PPP1R17, RGR, and C16orf90. Each is linked with CMTR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CMTR2-to-partner and partner-to-CMTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R17 grouped by CMTR2-low versus CMTR2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMTR2→partner) and Y-score (partner→CMTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PPP1R17 →	+0.033	+3.736	.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	RGR →	+0.042	+3.510	<.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	C16orf90 →	+0.018	+3.510	<.001	.007	3	1
BLOOD_Lymphoma	OR8D2 →	+0.074	+4.867	<.001	.009	3	1
SKIN	OR52E8 →	+0.032	+5.415	<.001	.004	3	1
SKIN	TMEM114 →	+0.051	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PPP1R17 by CMTR2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →