Across TCGA pan-cancer cohorts, CMTM4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CMTM4 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher CMTM4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CMTM4 expression acts as an unfavorable survival marker.

LUSC, UCEC, and LIHC are the cancer types where CMTM4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.002	0.776	<.001	24	view →
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
LIHC	DFS	Median	II,III,IV	0.044	0.427	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: CMTM4 tumor-vs-normal RNA expression · all CMTM4 data types