CMTM2

Across TCGA patient cohorts, CMTM2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMTM2-associated genes across cancer lineages are 14-3-3_beta, IGFBP2, and Akt_pT308. Each is linked with CMTM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CMTM2-to-partner and partner-to-CMTM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CMTM2-low versus CMTM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMTM2→partner) and Y-score (partner→CMTM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.122	-2.446	.012	.020	3	1
UCEC	IGFBP2 →	-1.075	-2.459	<.001	.020	3	1
UCEC	Akt_pT308 →	+0.758	+2.459	.012	.020	3	1
UCEC	PDK1_pS241 →	+0.188	+2.833	.022	.034	3	1
UCEC	PRAS40_pT246 →	+0.201	+2.472	.015	.011	3	1
UCEC	Rad50 →	-0.326	-2.986	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

14-3-3_beta by CMTM2 expression — UCEC

Explore this box plot interactively →