CMTM1

Across TCGA patient cohorts, CMTM1 mutation is significantly associated with the RNA expression of many other genes, with 896 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMTM1-associated genes across cancer lineages are PSPN, CHAF1A, and RANBP3. Each is linked with CMTM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CMTM1-to-partner and partner-to-CMTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSPN grouped by CMTM1-low versus CMTM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMTM1→partner) and Y-score (partner→CMTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSPN →	+0.398	+2.823	.001	.001	3	2
UCEC	CHAF1A →	+0.530	+3.108	.005	<.001	3	2
UCEC	RANBP3 →	+0.294	+3.491	.009	.002	3	2
UCEC	PNPLA6 →	+0.436	+2.863	.004	.001	3	2
UCEC	SIRT2 →	+0.377	+3.642	.003	.001	3	2
UCEC	POLRMT →	+0.411	+2.436	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 896 associations by consensus.

PSPN by CMTM1 expression — UCEC

Explore this box plot interactively →