Across TCGA patient cohorts, CMSS1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMSS1-associated genes across cancer lineages are Ku80, Notch1, and p62 Lck ligand. Each is linked with CMSS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CMSS1-to-partner and partner-to-CMSS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMSS1→partner) and Y-score (partner→CMSS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.301	+2.183	.004	.033	3	2
UCEC	Notch1 →	+0.172	+3.331	.006	.005	3	1
UCEC	p62 Lck ligand →	+0.355	+2.179	.015	.034	3	1
UCEC	Annexin-1 →	+0.590	+2.189	.012	.034	3	1
UCEC	STAT3_pY705 →	-0.511	-2.700	<.001	.006	3	1
UCEC	TFRC →	+0.607	+2.999	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

CMSS1 survival (RNA) · tumor vs normal (RNA) · all CMSS1 data types