CMPK2

Across TCGA patient cohorts, CMPK2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMPK2-associated genes across cancer lineages are Notch1, eIF4G, and INPP4B. Each is linked with CMPK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CMPK2-to-partner and partner-to-CMPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CMPK2-low versus CMPK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMPK2→partner) and Y-score (partner→CMPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.152	+2.594	.005	.006	3	2
UCEC	eIF4G →	+0.244	+1.584	.045	.036	3	1
UCEC	INPP4B →	-0.250	-2.000	.049	.030	3	1
UCEC	MEK1 →	+0.345	+2.115	.016	.017	3	1
UCEC	MSH2 →	-0.303	-3.295	<.001	.009	3	1
UCEC	mTOR_pS2448 →	-0.140	-2.308	.016	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Notch1 by CMPK2 expression — UCEC

Explore this box plot interactively →