CMKLR1

Across TCGA patient cohorts, CMKLR1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMKLR1-associated genes across cancer lineages are Annexin_VII, Paxillin, and PKC-delta_pS664. Each is linked with CMKLR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CMKLR1-to-partner and partner-to-CMKLR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin_VII grouped by CMKLR1-low versus CMKLR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMKLR1→partner) and Y-score (partner→CMKLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin_VII →	-0.109	-1.584	.046	.036	3	3
LUSC	Paxillin →	+0.516	+2.816	.018	.036	3	2
SKCM	PKC-delta_pS664 →	-0.162	-2.115	.020	.017	3	2
UCEC	Rab25 →	-0.277	-2.000	.033	.010	3	2
UCEC	TFRC →	+0.478	+2.000	.021	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.592	+3.479	.011	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Annexin_VII by CMKLR1 expression — UCEC

Explore this box plot interactively →