CMKLR1

Across TCGA cell cohorts, CMKLR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 773 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CMKLR1-associated GO terms across cancer lineages are Alpha-beta T cell lineage commitment, CD4-positive, alpha-beta T cell lineage commitment, and T-helper 17 cell lineage commitment. Each is linked with CMKLR1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CMKLR1-to-partner and partner-to-CMKLR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Alpha-beta T cell lineage commitment grouped by CMKLR1-low versus CMKLR1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CMKLR1→partner) and Y-score (partner→CMKLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Alpha-beta T cell lineage commitment →	+0.137	+1.054	<.001	.009	3	5
BLOOD_Leukemia	CD4-positive, alpha-beta T cell lineage commitment →	+0.082	+0.276	<.001	.003	3	5
SOFT_TISSUE	T-helper 17 cell lineage commitment →	+0.153	+0.772	.007	.002	3	4
CNS	T-helper cell lineage commitment →	+0.169	+1.159	<.001	.003	3	4
CNS	T cell lineage commitment →	+0.127	+0.829	.001	.009	3	4
SOFT_TISSUE	Regulation of protein modification by small protein conjugation or removal →	+0.029	+0.475	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 773 associations by consensus.

Alpha-beta T cell lineage commitment by CMKLR1 expression — CNS

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