CMKLR1

Across TCGA cell cohorts, CMKLR1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CMKLR1-associated genes across cancer lineages are TSHB, AWAT2, and HTR5A. Each is linked with CMKLR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CMKLR1-to-partner and partner-to-CMKLR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSHB grouped by CMKLR1-low versus CMKLR1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMKLR1→partner) and Y-score (partner→CMKLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TSHB →	+0.256	+4.276	<.001	.007	3	1
BLOOD_Leukemia	AWAT2 →	+0.015	+4.705	<.001	.003	3	1
BLOOD_Leukemia	HTR5A →	+0.035	+4.409	<.001	.005	3	1
BLOOD_Leukemia	MC2R →	+0.004	+4.969	<.001	.003	3	1
BLOOD_Leukemia	SLC36A2 →	+0.015	+4.551	<.001	.004	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.058	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

TSHB by CMKLR1 expression — BLOOD_Leukemia

Explore this box plot interactively →