CMIP

Across TCGA pan-cancer cohorts, CMIP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CMIP data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CMIP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CMIP expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

CCRCC, UCEC, and PDAC are the cancer types where CMIP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.670	0.903	.014	22	view →
UCEC	DFS	Tertile	All	1.000	0.881	.007	12	view →
PDAC	OS	Tertile	IV	0.425	0.962	.024	7	view →
LSCC	DFS	Quartile	II,III,IV	0.968	0.732	.026	3	view →
LUAD	DFS	Median	II,III,IV	0.754	0.991	.022	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CMIP–CCRCC (DFS)

Open the CCRCC breakdown →