CMIP

Across TCGA pan-cancer cohorts, CMIP mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CMIP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CMIP mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CMIP is over-expressed in tumor.

HNSC, LSCC, and PDAC are the cancer types where CMIP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CMIP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.404	<.001	10	view →
LSCC	Female	All	+0.582	<.001	9	view →
PDAC	All	III,IV	+0.545	<.001	9	view →
CCRCC	Male	III,IV	+0.325	<.001	9	view →
LUAD	Male	II,III,IV	+0.109	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CMIP–HNSC

Open the HNSC breakdown →