CMIP

Across TCGA patient cohorts, CMIP mutation is significantly associated with the RNA expression of many other genes, with 3,084 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMIP-associated genes across cancer lineages are CXXC1, SLC25A28, and PKN3. Each is linked with CMIP in more than 1 cancer types. Because this analysis shows association rather than direction, both CMIP-to-partner and partner-to-CMIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CXXC1 grouped by CMIP-low versus CMIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMIP→partner) and Y-score (partner→CMIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CXXC1 →	+0.430	+2.807	<.001	<.001	3	2
UCEC	SLC25A28 →	+0.276	+1.409	<.001	.002	3	2
UCEC	PKN3 →	+0.781	+2.247	<.001	<.001	3	2
UCEC	CFTR →	-0.907	-2.631	.001	<.001	3	2
UCEC	GFI1 →	+0.398	+1.805	<.001	<.001	3	2
UCEC	PLB1 →	-0.470	-1.773	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,084 associations by consensus.

CXXC1 by CMIP expression — UCEC

Explore this box plot interactively →