CMIP

Across TCGA patient cohorts, CMIP mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMIP-associated genes across cancer lineages are MEK1, 4E-BP1_pT37_T46, and Caspase-7-cleavedD198. Each is linked with CMIP in more than 1 cancer types. Because this analysis shows association rather than direction, both CMIP-to-partner and partner-to-CMIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CMIP-low versus CMIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMIP→partner) and Y-score (partner→CMIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.315	+1.807	.004	.003	3	2
UCEC	4E-BP1_pT37_T46 →	-0.281	-1.664	.013	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.491	+1.171	.006	.031	3	2
UCEC	4E-BP1 →	+0.289	+2.199	<.001	.001	3	2
UCEC	C-Raf →	+0.124	+1.125	.004	.033	3	2
UCEC	Cyclin-B1 →	+0.544	+2.807	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

MEK1 by CMIP expression — UCEC

Explore this box plot interactively →