CMC4

Across TCGA pan-cancer cohorts, CMC4 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CMC4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CMC4 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CMC4 is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

HNSC, PDAC, and LUAD are the cancer types where CMC4 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CMC4 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	−0.185	.003	9	view →
PDAC	Female	All	−1.474	<.001	8	view →
LUAD	Female	All	+0.640	<.001	6	view →
COAD	All	All	−0.251	.010	5	view →
CCRCC	All	All	−0.291	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CMC4–HNSC

Open the HNSC breakdown →