CMC2

Across TCGA patient cohorts, CMC2 protein abundance is significantly associated with the RNA expression of many other genes, with 8,824 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CMC2-associated genes across cancer lineages are PDGFRL, LHFPL6, and CENPN. Each is linked with CMC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CMC2-to-partner and partner-to-CMC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CMC2 versus PDGFRL in BRCA, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMC2→partner) and Y-score (partner→CMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PDGFRL →	-1.211	-0.418	<.001	<.001	3	4
CCRCC	LHFPL6 →	-0.967	-0.486	<.001	<.001	3	4
BRCA	CENPN →	+0.578	+0.375	<.001	<.001	3	4
CCRCC	TIMP3 →	-1.330	-0.493	<.001	<.001	3	4
BRCA	EDNRA →	-0.969	-0.368	<.001	<.001	3	4
BRCA	PRICKLE2 →	-0.702	-0.265	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,824 associations by consensus.

CMC2 vs PDGFRL — BRCA

Explore this scatter interactively →