Across TCGA patient cohorts, CMC1 mutation is significantly associated with the RNA expression of many other genes, with 598 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMC1-associated genes across cancer lineages are RN7SL97P, MDH1P2, and MTCO3P1. Each is linked with CMC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CMC1-to-partner and partner-to-CMC1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMC1→partner) and Y-score (partner→CMC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL97P →	+0.118	+2.446	<.001	.001	3	2
COAD	MDH1P2 →	+0.130	+3.792	<.001	.007	3	1
COAD	MTCO3P1 →	+0.197	+4.126	<.001	.004	3	1
COAD	NDUFB11P1 →	+0.617	+3.917	<.001	.007	3	1
COAD	CCT7P2 →	+0.175	+3.798	.008	.009	3	1
COAD	RN7SKP265 →	+0.258	+5.824	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 598 associations by consensus.

Exploration

CMC1 survival (RNA) · tumor vs normal (RNA) · all CMC1 data types