CMBL

Across TCGA pan-cancer cohorts, CMBL mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CMBL’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CMBL mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CMBL is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, COAD, and HNSC are the cancer types where CMBL tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CMBL mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	−0.864	<.001	11	view →
COAD	Female	III,IV	−1.101	<.001	10	view →
HNSC	All	II,III,IV	−0.806	<.001	8	view →
LSCC	All	All	−0.237	.002	4	view →
OV	All	All	−0.916	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CMBL–CCRCC

Open the CCRCC breakdown →