CMBL

Across TCGA patient cohorts, CMBL mutation is significantly associated with the RNA expression of many other genes, with 169 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMBL-associated genes across cancer lineages are MIR130A, TRAJ10, and NFYBP1. Each is linked with CMBL in more than 1 cancer types. Because this analysis shows association rather than direction, both CMBL-to-partner and partner-to-CMBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR130A grouped by CMBL-low versus CMBL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMBL→partner) and Y-score (partner→CMBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR130A →	+0.593	+2.967	<.001	.002	3	2
UCEC	TRAJ10 →	+0.908	+2.939	<.001	.001	3	2
UCEC	NFYBP1 →	+0.261	+2.572	<.001	.006	3	2
LUSC	LINC00613 →	+1.051	+5.211	<.001	.007	3	2
COAD	RNU6-83P →	+0.970	+4.962	<.001	.003	3	2
COAD	FAM138C →	+0.031	+4.807	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 169 associations by consensus.

MIR130A by CMBL expression — UCEC

Explore this box plot interactively →