CMAS

Across TCGA pan-cancer cohorts, CMAS mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CMAS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CMAS mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CMAS is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, CCRCC, and LSCC are the cancer types where CMAS tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CMAS mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−0.467	<.001	11	view →
CCRCC	Male	III,IV	+0.309	<.001	11	view →
LSCC	Male	II,III,IV	+0.277	<.001	6	view →
COAD	Female	All	−0.177	.010	4	view →
PDAC	Female	All	−0.349	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CMAS–HNSC

Open the HNSC breakdown →