CMAS

Across TCGA patient cohorts, CMAS mutation is significantly associated with the RNA expression of many other genes, with 3,754 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMAS-associated genes across cancer lineages are MIR8058, MIR4718, and MTCO2P3. Each is linked with CMAS in more than 2 cancer types. Because this analysis shows association rather than direction, both CMAS-to-partner and partner-to-CMAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8058 grouped by CMAS-low versus CMAS-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMAS→partner) and Y-score (partner→CMAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR8058 →	+1.072	+3.289	<.001	.008	3	3
LUAD	MIR4718 →	+0.451	+4.859	.002	.004	3	3
STAD	MTCO2P3 →	+0.469	+4.290	<.001	.008	3	3
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	2
READ	OR52E5 →	+0.057	+5.925	<.001	.002	3	2
UCEC	LINC02348 →	+0.296	+1.662	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,754 associations by consensus.

MIR8058 by CMAS expression — COAD

Explore this box plot interactively →