CMAS

Across TCGA patient cohorts, CMAS mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMAS-associated genes across cancer lineages are C-Raf, Akt_pT308, and Rad50. Each is linked with CMAS in more than 2 cancer types. Because this analysis shows association rather than direction, both CMAS-to-partner and partner-to-CMAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by CMAS-low versus CMAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMAS→partner) and Y-score (partner→CMAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.188	+1.807	<.001	.025	3	3
UCEC	Akt_pT308 →	+0.524	+2.584	.016	.010	3	2
UCEC	Rad50 →	-0.225	-2.459	.007	<.001	3	2
UCEC	ASNS →	+0.552	+2.662	<.001	<.001	3	2
UCEC	ATM →	-0.417	-1.986	.008	.029	3	2
UCEC	Cyclin-B1 →	+0.720	+3.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

C-Raf by CMAS expression — UCEC

Explore this box plot interactively →