CMAHP

Across TCGA patient cohorts, CMAHP mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CMAHP-associated genes across cancer lineages are Notch1, ASNS, and 14-3-3_beta. Each is linked with CMAHP in more than 1 cancer types. Because this analysis shows association rather than direction, both CMAHP-to-partner and partner-to-CMAHP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CMAHP-low versus CMAHP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CMAHP→partner) and Y-score (partner→CMAHP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.167	+3.594	.002	.001	3	2
UCEC	ASNS →	+0.472	+3.700	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.110	-1.986	.005	.010	3	1
UCEC	eEF2 →	+0.310	+2.321	.027	.033	3	1
UCEC	EGFR_pY1068 →	-0.352	-3.169	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.222	-3.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Notch1 by CMAHP expression — UCEC

Explore this box plot interactively →