CLVS2

Across TCGA patient cohorts, CLVS2 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,183 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CLVS2-associated proteins across cancer lineages are TPPP, PRKAR2B, and ARHGEF7_S25. Each is linked with CLVS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CLVS2-to-partner and partner-to-CLVS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLVS2 versus TPPP in GBM, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CLVS2→partner) and Y-score (partner→CLVS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TPPP →	+0.785	+1.237	<.001	<.001	3	4
UCEC	PRKAR2B →	+0.601	+0.295	<.001	.008	3	3
UCEC	ARHGEF7_S25 →	+0.940	+0.307	<.001	.008	3	3
GBM	PIN1 →	+0.258	+0.870	<.001	<.001	3	3
UCEC	PPM1F →	+0.231	+0.303	<.001	.006	3	3
GBM	PTBP2_S308 →	+0.711	+1.076	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,183 associations by consensus.

CLVS2 vs TPPP — GBM

Explore this scatter interactively →