CLVS2

Across TCGA cell cohorts, CLVS2 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CLVS2-associated genes across cancer lineages are MSGN1, CPLX4, and FAM153B. Each is linked with CLVS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLVS2-to-partner and partner-to-CLVS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by CLVS2-low versus CLVS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLVS2→partner) and Y-score (partner→CLVS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.095	+4.345	<.001	<.001	3	1
LARGE_INTESTINE	CPLX4 →	+0.021	+3.766	.006	.004	3	1
LARGE_INTESTINE	FAM153B →	+0.630	+3.748	<.001	.004	3	1
LARGE_INTESTINE	TAFA1 →	+0.280	+3.688	<.001	.002	3	1
LARGE_INTESTINE	DAZ4 →	+0.164	+3.977	<.001	.001	3	1
LARGE_INTESTINE	RBMY1J →	+0.006	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MSGN1 by CLVS2 expression — LARGE_INTESTINE

Explore this box plot interactively →