CLVS2

Across TCGA cell cohorts, CLVS2 mutation is significantly associated with the mutation status of many other genes, with 2,678 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLVS2-associated genes across cancer lineages are SLC4A3, BICC1, and NGFR. Each is linked with CLVS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLVS2-to-partner and partner-to-CLVS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC4A3 grouped by CLVS2-low versus CLVS2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLVS2→partner) and Y-score (partner→CLVS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC4A3 →	+3.832	+4.316	.002	.002	1	3
BLOOD_Lymphoma	BICC1 →	+4.247	+4.554	.001	.001	1	3
BLOOD_Lymphoma	NGFR →	+5.247	+4.429	.005	.005	1	3
BLOOD_Lymphoma	GNAS →	+3.025	+3.754	.006	.006	1	3
LUNG_SCLC	NOVA1 →	+4.193	+2.843	.007	.007	1	3
LUNG_SCLC	ASAP2 →	+4.193	+2.843	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,678 associations by consensus.

SLC4A3 by CLVS2 expression — BLOOD_Lymphoma

Explore this box plot interactively →