CLUL1

Across TCGA patient cohorts, CLUL1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLUL1-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and Chk2. Each is linked with CLUL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLUL1-to-partner and partner-to-CLUL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CLUL1-low versus CLUL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLUL1→partner) and Y-score (partner→CLUL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.228	-2.000	.021	.010	3	2
UCEC	eIF4E →	+0.209	+3.335	.011	.005	3	2
UCEC	Chk2 →	-0.181	-2.000	.049	.030	3	2
UCEC	Di-Ras3 →	-0.119	-2.000	.040	.010	3	2
UCEC	E-Cadherin →	-0.423	-2.449	.026	.019	3	2
UCEC	eEF2 →	+0.363	+3.321	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by CLUL1 expression — UCEC

Explore this box plot interactively →