CLU

Across TCGA pan-cancer cohorts, CLU mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CLU data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CLU mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CLU expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

COAD, LUAD, and UCEC are the cancer types where CLU mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.879	1.000	.014	72	view →
LUAD	OS	Median	III,IV	0.330	0.869	.006	40	view →
UCEC	DFS	Tertile	III,IV	0.232	0.847	.019	12	view →
GBM	DFS	Tertile	All	0.231	0.483	.002	11	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	11	view →
LSCC	DFS	Median	II,III,IV	0.866	0.969	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CLU–COAD (DFS)

Open the COAD breakdown →