CLU

Across TCGA patient cohorts, CLU mutation is significantly associated with the RNA expression of many other genes, with 2,616 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLU-associated genes across cancer lineages are TXN2P1, MIR4726, and NGRN. Each is linked with CLU in more than 2 cancer types. Because this analysis shows association rather than direction, both CLU-to-partner and partner-to-CLU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXN2P1 grouped by CLU-low versus CLU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLU→partner) and Y-score (partner→CLU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TXN2P1 →	+0.201	+2.906	.008	<.001	3	3
BRCA	MIR4726 →	+0.416	+4.797	<.001	.005	3	2
UCEC	NGRN →	+0.631	+3.928	<.001	<.001	3	2
SKCM	MX2 →	-0.927	-3.434	.007	.005	3	2
UCEC	RPL23AP82 →	+0.348	+2.010	.002	.001	3	2
UCEC	UBE2L3 →	+0.369	+3.774	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,616 associations by consensus.

TXN2P1 by CLU expression — UCEC

Explore this box plot interactively →