CLU

Across TCGA patient cohorts, CLU mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLU-associated genes across cancer lineages are Caspase-7-cleavedD198, INPP4B, and p62 Lck ligand. Each is linked with CLU in more than 2 cancer types. Because this analysis shows association rather than direction, both CLU-to-partner and partner-to-CLU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CLU-low versus CLU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLU→partner) and Y-score (partner→CLU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.832	+2.720	<.001	.003	3	3
UCEC	INPP4B →	-0.312	-3.584	.016	.002	3	2
UCEC	p62 Lck ligand →	+0.314	+2.415	.016	.003	3	2
UCEC	STAT3_pY705 →	-0.454	-2.115	<.001	.016	3	2
SKCM	TFRC →	+0.553	+3.169	.018	.017	3	2
UCEC	VHL →	-0.962	-1.700	<.001	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Caspase-7-cleavedD198 by CLU expression — UCEC

Explore this box plot interactively →