CLU

Across TCGA cell cohorts, CLU RNA expression is significantly associated with the go_rna of many other GO terms, with 5,687 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CLU-associated GO terms across cancer lineages are Negative regulation of complement-dependent cytotoxicity, Immune complex clearance, and Regulation of activation of membrane attack complex. Each is linked with CLU in more than 19 cancer types. Because this analysis shows association rather than direction, both CLU-to-partner and partner-to-CLU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of complement-dependent cytotoxicity grouped by CLU-low versus CLU-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLU→partner) and Y-score (partner→CLU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of complement-dependent cytotoxicity →	+0.466	+3.798	<.001	<.001	3	20
LUNG_SCLC	Immune complex clearance →	+1.664	+4.148	<.001	<.001	3	20
BLOOD_Lymphoma	Regulation of activation of membrane attack complex →	+0.500	+3.555	<.001	<.001	3	19
BLOOD_Lymphoma	Negative regulation of activation of membrane attack complex →	+0.421	+3.879	<.001	<.001	3	19
BLOOD_Myeloma	Protein import →	+0.377	+4.707	<.001	<.001	3	18
LUNG_SCLC	Protein targeting to vacuole involved in autophagy →	+0.270	+5.264	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,687 associations by consensus.

Negative regulation of complement-dependent cytotoxicity by CLU expression — BLOOD_Lymphoma

Explore this box plot interactively →