CLTCL1

Across TCGA patient cohorts, CLTCL1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLTCL1-associated genes across cancer lineages are Cyclin-B1, PDCD4, and Stathmin. Each is linked with CLTCL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CLTCL1-to-partner and partner-to-CLTCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CLTCL1-low versus CLTCL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLTCL1→partner) and Y-score (partner→CLTCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.580	+1.784	<.001	<.001	3	4
UCEC	PDCD4 →	-0.460	-1.678	<.001	.019	3	3
UCEC	Stathmin →	+0.096	+1.054	.013	.029	3	3
UCEC	Caspase-7-cleavedD198 →	+0.666	+1.847	<.001	.007	3	3
UCEC	MEK1 →	+0.379	+1.584	<.001	.001	3	2
UCEC	eIF4E →	+0.190	+4.013	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Cyclin-B1 by CLTCL1 expression — UCEC

Explore this box plot interactively →