CLTCL1

Across TCGA cell cohorts, CLTCL1 mutation is significantly associated with the RNA expression of many other genes, with 847 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLTCL1-associated genes across cancer lineages are GALR3, MAP3K10, and GPD1L. Each is linked with CLTCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CLTCL1-to-partner and partner-to-CLTCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALR3 grouped by CLTCL1-low versus CLTCL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLTCL1→partner) and Y-score (partner→CLTCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GALR3 →	+0.087	+3.628	<.001	<.001	3	2
LARGE_INTESTINE	MAP3K10 →	+0.571	+2.502	.009	.005	3	2
LARGE_INTESTINE	GPD1L →	+0.704	+3.628	.002	<.001	3	2
LARGE_INTESTINE	CES3 →	+1.271	+3.082	.005	.007	3	2
LARGE_INTESTINE	KLHL11 →	+0.647	+2.502	.007	.005	3	2
LARGE_INTESTINE	MRPL42 →	+0.635	+3.628	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 847 associations by consensus.

GALR3 by CLTCL1 expression — LARGE_INTESTINE

Explore this box plot interactively →