CLTCL1

Across TCGA cell cohorts, CLTCL1 mutation is significantly associated with the mutation status of many other genes, with 7,015 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLTCL1-associated genes across cancer lineages are ELOA, MYH9, and ZMYM3. Each is linked with CLTCL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CLTCL1-to-partner and partner-to-CLTCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA grouped by CLTCL1-low versus CLTCL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLTCL1→partner) and Y-score (partner→CLTCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ELOA →	+5.080	+3.390	<.001	<.001	1	5
UPPER_AERODIGESTIVE_TRACT	MYH9 →	+3.608	+3.906	.004	.004	1	5
UPPER_AERODIGESTIVE_TRACT	ZMYM3 →	+3.608	+3.906	.004	.004	1	5
CNS	HECTD1 →	+5.000	+4.044	.008	.008	1	5
LUNG_NSCLC_LUAD	DDB1 →	+4.187	+5.000	.008	.008	1	5
LUNG_NSCLC_LUAD	CDC45 →	+5.772	+5.772	.002	.002	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,015 associations by consensus.

ELOA by CLTCL1 expression — BLOOD_Leukemia

Explore this box plot interactively →