CLTC

Across TCGA pan-cancer cohorts, CLTC mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CLTC data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CLTC mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CLTC expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

UCEC, LUAD, and COAD are the cancer types where CLTC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.944	0.469	.003	22	view →
LUAD	DFS	Median	All	0.550	1.000	<.001	19	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.921	.047	6	view →
LSCC	DFS	Quartile	All	0.857	1.000	.010	4	view →
PDAC	DFS	Tertile	IV	0.203	0.752	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CLTC–UCEC (DFS)

Open the UCEC breakdown →