CLTC

Across TCGA patient cohorts, CLTC protein abundance is significantly associated with the RNA expression of many other genes, with 9,394 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CLTC-associated genes across cancer lineages are GLT1D1, VMP1, and MICU1. Each is linked with CLTC in more than 3 cancer types. Because this analysis shows association rather than direction, both CLTC-to-partner and partner-to-CLTC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CLTC versus GLT1D1 in UCEC, with a Pearson correlation of -0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLTC→partner) and Y-score (partner→CLTC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GLT1D1 →	-0.791	-0.207	<.001	<.001	3	4
BRCA	VMP1 →	+0.890	+0.185	<.001	<.001	3	4
PDAC	MICU1 →	+0.391	+0.243	<.001	<.001	3	4
GBM	ATP6V1E1 →	+0.442	+0.269	<.001	<.001	3	4
GBM	ANKRD40 →	+0.350	+0.161	<.001	.002	3	4
UCEC	BSPRY →	+0.706	+0.128	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,394 associations by consensus.

CLTC vs GLT1D1 — UCEC

Explore this scatter interactively →