CLTC

Across TCGA patient cohorts, CLTC mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLTC-associated genes across cancer lineages are ATM, PKC-a, and eIF4E. Each is linked with CLTC in more than 3 cancer types. Because this analysis shows association rather than direction, both CLTC-to-partner and partner-to-CLTC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CLTC-low versus CLTC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLTC→partner) and Y-score (partner→CLTC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.567	-1.906	<.001	<.001	3	4
SKCM	PKC-a →	-0.445	-3.169	.022	.018	3	3
UCEC	eIF4E →	+0.121	+1.920	.048	.008	3	3
UCEC	TSC1 →	-0.113	-1.638	.023	.020	3	3
UCEC	Caspase-7-cleavedD198 →	+0.665	+2.662	<.001	<.001	3	3
BLCA	eEF2 →	+0.313	+3.459	.003	.005	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

ATM by CLTC expression — UCEC

Explore this box plot interactively →