CLTC

Across TCGA cell cohorts, CLTC RNA expression is significantly associated with the go_rna of many other GO terms, with 3,869 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CLTC-associated GO terms across cancer lineages are Negative regulation of beige fat cell differentiation, Organelle transport along microtubule, and Endosomal transport. Each is linked with CLTC in more than 16 cancer types. Because this analysis shows association rather than direction, both CLTC-to-partner and partner-to-CLTC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of beige fat cell differentiation grouped by CLTC-low versus CLTC-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CLTC→partner) and Y-score (partner→CLTC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of beige fat cell differentiation →	+0.172	+1.035	<.001	<.001	3	17
LIVER	Organelle transport along microtubule →	+0.074	+0.932	<.001	.001	3	11
CNS	Endosomal transport →	+0.046	+0.416	<.001	.004	2	11
BREAST	Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway →	+0.090	+0.884	<.001	.001	3	10
OESOPHAGUS	Phospholipid dephosphorylation →	+0.078	+0.893	.005	.005	3	10
OVARY	Mitotic cytokinesis →	+0.071	+0.655	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,869 associations by consensus.

Negative regulation of beige fat cell differentiation by CLTC expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →