CLTC

Across TCGA cell cohorts, CLTC mutation is significantly associated with the RNA expression of many other genes, with 392 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CLTC-associated genes across cancer lineages are OR2A2, OTP, and FAM205A. Each is linked with CLTC in more than 1 cancer types. Because this analysis shows association rather than direction, both CLTC-to-partner and partner-to-CLTC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2A2 grouped by CLTC-low versus CLTC-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLTC→partner) and Y-score (partner→CLTC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OR2A2 →	+0.046	+5.087	<.001	.004	3	2
LARGE_INTESTINE	OTP →	+0.049	+3.076	<.001	<.001	3	2
LARGE_INTESTINE	FAM205A →	+0.013	+1.959	<.001	.001	3	2
SKIN	KLRD1 →	+0.246	+3.914	.002	.005	3	2
BLOOD_Leukemia	SLC35G3 →	+0.046	+3.704	<.001	.001	3	2
URINARY_TRACT	LRIT2 →	+0.036	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 392 associations by consensus.

OR2A2 by CLTC expression — URINARY_TRACT

Explore this box plot interactively →