CLTB

Across TCGA pan-cancer cohorts, CLTB mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of CLTB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CLTB mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CLTB is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and LSCC are the cancer types where CLTB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CLTB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−0.519	<.001	12	view →
CCRCC	Male	All	−0.333	<.001	12	view →
LSCC	All	All	−0.209	<.001	8	view →
HNSC	Male	IV	−0.256	.010	7	view →
PDAC	All	All	+0.180	.004	4	view →
OV	All	All	−0.390	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

CLTB–COAD

Open the COAD breakdown →