CLTB

Across TCGA patient cohorts, CLTB mutation is significantly associated with the RNA expression of many other genes, with 972 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLTB-associated genes across cancer lineages are COX6CP12, RN7SL745P, and SPINT3. Each is linked with CLTB in more than 1 cancer types. Because this analysis shows association rather than direction, both CLTB-to-partner and partner-to-CLTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6CP12 grouped by CLTB-low versus CLTB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLTB→partner) and Y-score (partner→CLTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	COX6CP12 →	+0.173	+4.513	<.001	.009	3	2
UCEC	RN7SL745P →	+0.263	+2.491	.008	<.001	3	2
CESC	SPINT3 →	+0.090	+4.539	<.001	.008	3	1
CESC	C16orf78 →	+0.051	+4.455	<.001	.005	3	1
CESC	RNU6-235P →	+0.280	+4.669	<.001	.007	3	1
CESC	RNA5SP205 →	+0.221	+6.164	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 972 associations by consensus.

COX6CP12 by CLTB expression — SKCM

Explore this box plot interactively →