CLTB

Across TCGA patient cohorts, CLTB mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLTB-associated genes across cancer lineages are Notch1, p27_pT198, and Annexin-1. Each is linked with CLTB in more than 1 cancer types. Because this analysis shows association rather than direction, both CLTB-to-partner and partner-to-CLTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CLTB-low versus CLTB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLTB→partner) and Y-score (partner→CLTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.191	+3.179	.003	.010	3	1
UCEC	p27_pT198 →	+0.118	+2.584	.018	.011	3	1
UCEC	Annexin-1 →	+0.532	+3.019	.030	.019	3	1
UCEC	Caspase-7-cleavedD198 →	+0.817	+2.321	.003	.033	3	1
UCEC	Caspase-8 →	-0.231	-3.459	.048	.005	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Notch1 by CLTB expression — UCEC

Explore this box plot interactively →