CLSTN3

Across TCGA patient cohorts, CLSTN3 mutation is significantly associated with the RNA expression of many other genes, with 4,530 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLSTN3-associated genes across cancer lineages are TRIM25, CRYBB2P1, and PLEKHA1. Each is linked with CLSTN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CLSTN3-to-partner and partner-to-CLSTN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM25 grouped by CLSTN3-low versus CLSTN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLSTN3→partner) and Y-score (partner→CLSTN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRIM25 →	+0.404	+2.625	.001	<.001	3	4
UCEC	CRYBB2P1 →	+0.487	+1.968	<.001	<.001	3	3
UCEC	PLEKHA1 →	+0.536	+2.949	<.001	<.001	3	3
SKCM	HMGCR →	+0.636	+3.009	.001	<.001	3	3
SKCM	PSMB2 →	+0.318	+2.436	.003	<.001	3	3
SKCM	UBAC1 →	+0.431	+3.738	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,530 associations by consensus.

TRIM25 by CLSTN3 expression — UCEC

Explore this box plot interactively →