CLSTN3

Across TCGA patient cohorts, CLSTN3 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CLSTN3-associated genes across cancer lineages are MEK1, p53, and FASN. Each is linked with CLSTN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CLSTN3-to-partner and partner-to-CLSTN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CLSTN3-low versus CLSTN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CLSTN3→partner) and Y-score (partner→CLSTN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.344	+2.415	.006	.003	3	3
UCEC	p53 →	-0.309	-3.169	.021	.018	3	3
COAD	FASN →	+0.634	+3.008	.001	.019	3	2
COAD	INPP4B →	-0.462	-2.991	.017	.036	3	2
COAD	ATM →	-0.609	-2.991	.002	.036	2	3
UCEC	Cyclin-B1 →	+0.692	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

MEK1 by CLSTN3 expression — UCEC

Explore this box plot interactively →